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TETRAHYDROFURAN

CAS:109-99-9

Tetrahydrofuran (THF) is an important organic solvent

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TETRAHYDROFURAN

Tetrahydrofuran (THF) is an important organic solvent

Technical Specifications

  • Appearance: Colorless transparent liquid with an ethane-like odor
  • Melting point: -108.4°C
  • Boiling point: 66°C
  • Density: 0.889 g/cm³ (20°C)
  • Flash point: -14°C
  • Refractive index: 1.407
  • Solubility:
    • Miscible with water, alcohol, ether, chloroform and other solvents.
    • Polar solvent dissolving organic/inorganic compounds
  • Stability:
    • Relatively stable at room temperature
    • Forms explosive peroxide with air oxidation
  • Reactivity:
    • Catalyzed reaction with ammonia (300-400°C) yields pyrrolidine
    • Reaction with hydrogen sulfide (400°C) produces thiophene

Applications

  • Organic synthesis:
    • Solvent for Grignard reaction, Williamson ether synthesis
    • Polymerization solvent (polystyrene, polymethyl methacrylate)
  • Pharmaceutical Industry:
    • Synthesis of antibiotics/anticancer drug intermediates
  • Materials Science:
    • Synthesis of polytetrahydrofuran (PTFE) for engineering plastics
  • Electronics Industry:
    • Cleaning agent for electronic components
  • Other applications:
    • Coatings/inks production (film-forming properties)
    • Synthesis of fragrances and cosmetic ingredients

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